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Juvenile Psoriasisarthritis

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Pädiatrische Rheumatologie

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Zusammenfassung

Die juvenile Psoriasis-Arthritis (JPsA) stellt eine Subform der juvenilen idiopathischen Arthritis dar, welche seit mehr als 15 Jahren auch in den pädiatrischen Klassifikationskriterien der ILAR definiert wird. Da die Arthritis bei Kindern häufig vor Psoriasis-Läsionen auftritt, ist das frühe Erkennen dieser Subform der Arthritis aufgrund weiterer Kriterien wie Daktylitis, Nagelveränderungen oder Familienanamnese zielführend. In diesem Beitrag werden ausführlich die Entwicklung der Klassifikationskriterien und die Bemühungen zur frühzeitigen Diagnostik der juvenilen Psoriasis-Arthritis zusammengefasst. Zur Ursache der Erkrankung ist noch wenig bekannt, in den letzten Jahren wurde aber sehr viel zu genetischen Faktoren sowie zur Pathogenese und den beteiligten Zytokinen publiziert. Mit dem zunehmenden Verständnis der beteiligten Zytokine kommt gegenwärtig auch eine Vielzahl von neuen Wirksubstanzen in der Therapie der JPsA zum Einsatz; besonders vielversprechend sind hier die Gruppen der TNF-α-Inhibitoren, der T-Zell-Kostimulationsblocker sowie der gegen IL-12, IL-23, IL-17a und IL-17-Rezeptor gerichteten Wirkstoffe. Darüber hinaus werden derzeit Substanzen mit neuem Wirkprinzip, wie z. B. Phosphodiesterase-Inhibition oder Januskinase-lnhibition, hinsichtlich ihrer Wirksamkeit und Verträglichkeit bei der Therapie der juvenilen Psoriasis-Arthritis geprüft.

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Authors and Affiliations

  1. Abteilung für Kinder- und Jugendheilkunde, Landeskrankenhaus Bregenz, Bregenz, Österreich

    Christian Huemer

  2. Klinik für Pädiatrie m.S. Pneumologie, Immunologie und Intensivmedizin, Charité – Universitätsmedizin Berlin und Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Deutschland

    Kirsten Minden

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Correspondence to Christian Huemer .

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Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Aachen, Aachen, Deutschland

    Norbert Wagner

  2. Sektion Rheumatologie der Klinik für Pädiatrie m.S. Pneumologie, Immunologie und Intensivmedizin mit Bereich Rheumatologie, im Sozialpädiatrischen ZentrumCharité - Universitätsmedizin Berlin, Berlin, Deutschland

    Günther Dannecker

  3. Sektion Rheumatologie der Klinik für Pädiatrie m.S. Pneumologie, Immunologie und Intensivmedizin mit Bereich Rheumatologie, im Sozialpädiatrischen ZentrumCharité - Universitätsmedizin Berlin, Berlin, Deutschland

    Tilmann Kallinich

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Huemer, C., Minden, K. (2022). Juvenile Psoriasisarthritis. In: Wagner, N., Dannecker, G., Kallinich, T. (eds) Pädiatrische Rheumatologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60410-6_30

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