Diagnosis ka pkdl by dr shahjada_selim

Diagnosis of Kala-azar
and PKDL
Dr Shahjada Selim
MBBS MD (EM)
Registrar (Medicine), ShSMCH, Dhaka
email: selimshahjada@gmail.com

Clinical Case definition for Kala-azar and PKDL
The diagnosis of Kala-azar will be based on the
following criteria in a symptomatic case.
 History of fever for more than 2 weeks
 Residing/ traveling in endemic areas
 Any one of the following symptoms and signs:
Splenomegaly
Weight loss
Anemia
 And ‘rk39’ test positive.

Post Kala-azar Dermal Leishmaniasis
(PKDL)
PKDL should be considered if all of the following
features are present.
 Residing / travelling in the endemic areas
 History of treatment for Kala-azar any time in the past1
.
 Suggestive skin lesion without loss of sensation, which may be macular,
papular, nodular or mixed.
 Exclusion of other causes of skin disease eg. Leprosy, Vitiligo, Pityriasis,
Ring worm etc.
 Rk39 positive2
/ Slit skin smear positive/ PCR positive.
1
In rare instances h/o treatment of Kala-azar may be absent in PKDL.
2
In Rare instances in PKDL rk39 may be negative and should be diagnosed
by slit skin smear.

Case definition for reporting
Following clinical case definitions will be used for reporting
and follow up. The case definitions will be as follows-
Primary Kala-azar (PKA):
An individual who is diagnosed to have KA with the
above mentioned case definition and no history of
treatment for KA before will be considered as
primary Kala-azar (PKA).

Clinical Case Definition
Kala-azar Treatment Failure (KATF):
An individual, who is diagnosed to have KA with the above
mentioned case definition and history of treatment for KA
within last one year, will be reported as KATF. All efforts
should be made to diagnose KATF parasitologically by
examination of splenic smear or bone marrow or PCR.

Relapse Kala-azar (RKA):
An individual who is diagnosed to have KA with
the above mentioned case definition and history of
treatment for KA anytime in the past but not
within last one year will be reported as RKA. All
efforts should be made to diagnose KATF
parasitologically by examination of splenic smear
or bone marrow or PCR.

Post Kala-azar Dermal Leishmaniasis (PKDL):
An individual who is diagnosed to have PKDL with the above
mentioned case definition will be reported as PKDL.
Cutaneous Leishmaniasis (CL):
CL should be suspected in a person or a case of skin ulcer
(single or multiple) that travelled an endemic area (Middle
East, South America, Africa etc.). CL should always be
confirmed by demonstration of parasite from the lesion by slit
skin smear or parasite DNA in tissue specimen.

Diagnosis of Kala-azar in special situations
The diagnosis of Kala-azar can be difficult in special
situations. The common special situations are Kala-azar-TB
co-infection, Kala-azar-HIV co-infection, Kala-azar in
pregnancy etc. All efforts should be made to diagnose KA
in special situation by parasitological examination of
splenic smear or bone marrow or PCR. In cases of Kala-
azar HIV co-infection 'rK39' test may be negative. Patients
with Kala-azar in special situations should be referred to the
required level of facility as appropriate.

Location for Kala-azar and PKDL diagnosis
A) Level 1
In endemic areas in (union sub centre, community clinic or others)
1. Identify cases of fever of more than 2 weeks duration
2. Identify cases who have macular, papular or nodular skin lesions but no other
signs
3. Refer the patients with above problems to Upazila health complex for evaluation,
testing and treatment for Kala-azar or PKDL.
In endemic areas in upazila health complex
1. Check patients with fever of more than 2 weeks associated with splenomegaly
2. Check patients with macular, nodular or mixed lesions without loss of sensation.
Perform ‘rK39’ test :
(a) On all patients with fever of more than 2 weeks and have splenomegaly
(b) Patients with macular, papular or nodular or mixed lesions and no loss of
sensation.
3.Treat patients of Kala-azar with first line drugs
4. Refer PKDL cases whose need tissue biopsy and unresponsive cases of Kala-
azar to level III facility.

Location for Kala-azar and PKDL diagnosis
B) Level II
1. Check patients with fever of more than 2 weeks associated with splenomegaly.
2. Check patients with macular, nodular or mixed lesions without loss of sensation.
Perform ‘rK39’ test :
(a) On all patients with fever of more than 2 weeks and have splenomegaly
(b) Patients with macular or nodular or mixed lesions and no loss of sensation.
3. Treat patients of Kala-azar with first line drugs
4. Refer PKDL cases to who need tissue biopsy and unresponsive cases of Kala-azar to level
III facility.
C) Level III
1. Treat unresponsive Kala-azar or KATF cases and refer back of PKDL cases to level I and II
for treatment after tissue diagnosis.
2. Perform the slit skin smear/biopsy in suspected cases of PKDL that are ‘rK39’ test negative
3. Perform bone marrow / splenic aspiration in patients where these are indicated, as a part of
drug monitoring studies or as a part of quality assessment
4. Treat any complications associated with bone marrow/ splenic aspirate
D) Level IV (specialized laboratories)
1. Perform PCR test for establishing the diagnosis of PKDL in cases that are suspected to have
the disease but ‘rK39’test is negative
2. Diagnosis of HIV-Kala-azar co-infection may be done by bone marrow/ splenic aspirate

Associated Laboratory Investigations
• Complete Blood Count & Peripheral Blood Film
• High ESR
• Progressive Neutropenia
• Relative Lymphocytosis
•Serum Creatinine
•Serum ALT
• BT CT
•Abdominal Ultrasonogram

Diagnosis ka pkdl by dr shahjada_selim

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